書誌事項
- タイトル別名
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- Clinical manifestations and etiology in stroke patients with cancer: usefulness of coagulation and fibrinolytic markers
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OBJECTIVE : We analyzed the incidence and types of strokes in cancer patients, and evaluated the clini-cal utility of coagulation and fibrinolytic markers in cancer patients as compared to non-cancer patients.<BR>METHODS : A retrospective review of all ischemic strokes between January 2000 and December 2005 was conducted. Seventy-four patients (males, 53; females, 21) were identified. Age, gender, cancer diagnosis and histology, and vascular risk factors were recorded. The following coagulation and fibrinolytic parameters were examined : thrombin-antithrombin III complex (TAT), FDP D-dimer, α2-plasmin inhibitor/plasmin complex (PIC), antithrombin III (AT-III), fibrinogen (FIB), and platelet cell count.<BR>RESULTS: The strokes were embolic in 45 patients (60.8%) and thrombotic in 29(39.2%). The most com-mon primary tumor was gastric cancer (23%). The most common histopathology was adenocarcinoma (60.8%). Both mean D-dimer levels were higher in the malignant patients as compared to the controls (D-dimer: 15.4 ± 21.6μg/ml vs. 3.9 ± 6.8μg/ml, p<0.05). An increased serum CA19-9 level was correlated with the serum D-dimer level (CA19-9 vs. D-dimer : R = 0.37, p<0.05) .<BR>CONCLUSION : Activation of the coagulation system in cancer patients was more closely related to the cause of stroke than in patients without cancer ; that is to say, increased serum D-dimer levels might have the possibility to become predictors of stroke onset.
収録刊行物
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- 脳卒中
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脳卒中 28 (3), 351-359, 2006
一般社団法人 日本脳卒中学会
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詳細情報 詳細情報について
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- CRID
- 1390001204638313472
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- NII論文ID
- 130003631671
- 10018392879
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- NII書誌ID
- AN0020186X
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- ISSN
- 18831923
- 09120726
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
