Pooled analysis of clinical reports on edaravone using the technique of meta-analysis

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  • エダラボン臨床報告併合解析(メタアナリシスの手法を用いて)

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Abstract

An analysis of published clinical studies was made using the technique of meta-analysis to evaluate the effectiveness of edaravone, a brain-protective agent, against lacunar infarction. An electronic information search was conducted employing three key words (edaravone, stroke, and humans), and abstracts from major scientific meetings were explored by undertaking a manual search for the abstracts. The authors of the extracted reports were asked to cooperate with the study and to provide related data. From the 35 reports for which authors' approval was obtained, we selected those which met the following criteria for metaanalysis : (1) studies involving a control group and 10 or more patients treated with edaravone, (2) studies in which mRS was one of the variables analyzed, and (3) there was no significant difference in severity on admission between the edaravone-treated group and the control group. The selected 14 reports were subjected to pooled-analysis for the effectiveness of edaravone against lacunar infarction. When the functional outcome of the patients with lacunar infarction was evaluated using the percentage of cases rated as mRS 0-1, the outcome was slightly better in the edaravone-treated group, with an odds ratio of 1.41 (95%CI : 1.01-1.97), and this difference was statistically significant. These findings suggest that the functional outcome of patients with lacunar infarction can be improved by treatment with edaravone.

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