Clinical study on seven patients with migraine-related stroke

DOI 24 References
  • Iijima Mutsumi
    Department of Neurology, Neurological Institute, Tokyo Women's Medical University
  • Uchiyama Shinichiro
    Department of Neurology, Neurological Institute, Tokyo Women's Medical University
  • Yoshizawa Hiroshi
    Department of Neurology, Neurological Institute, Tokyo Women's Medical University
  • Terashi Hiromi
    Department of Neurology, Neurological Institute, Tokyo Women's Medical University
  • Masuda Yoko
    Department of Neurology, Neurological Institute, Tokyo Women's Medical University
  • Matsumura Miyuki
    Department of Neurology, Neurological Institute, Tokyo Women's Medical University
  • Tsutsumi Yukiko
    Department of Neurology, Neurological Institute, Tokyo Women's Medical University
  • Iwata Makoto
    Department of Neurology, Neurological Institute, Tokyo Women's Medical University

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  • 脳梗塞を併発した片頭痛７症例の臨床的検討

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Abstract

Background and purpose : Migraine is a rare but important etiologic factor of brain infarction in young people. We investigated the relationship between migraine and brain infarction.<BR>Methods : Seven patients (6 females and one male) who suffered brain infarction after migraine attacks were included. The mean age at cerebral infarction was 30.0 (range, 22 to 45) years old.<BR>Results : Two patients suffered migraine with aura and 5 patients suffered migraine without aura before the brain infarction. Six patients had vertebral-basilar and posterior cerebral artery lesions and one patient had middle cerebral artery lesions. None of the patients had hypertension, hyperlipidemia, diabetes, or cardiogenic diseases. Beta-thromboglobulin and platelet factor IV were elevated in 85.7% of the patients. Antinuclear antibody was positive in 57.1 % of the patients. One patient was IgM anti-cardiolipin antibody positive, and 2 patients were lupus anticoagulant positive.<BR>Conclusion : Our results suggested that brain infarction can be caused by exposure to a hypercoagulable state, and could be related to autoimmune abnormalities or anti-phospholipid antibodies.

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