A Case of Severe Falciparum Malaria Successfully Treated with Intravenous Artesunate and Continuous Hemodiafiltration

• MIZUNO Yasutaka

  Disease Control and Prevention Center

• FUJIMOTO Hitomi

  AIDS Clinical Center

• YOKOTA Kyoko

  AIDS Clinical Center

• KATO Yasuyuki

  Disease Control and Prevention Center

• GENKA Ikumi

  Disease Control and Prevention Center AIDS Clinical Center

• KANAGAWA Shuzo

  Disease Control and Prevention Center

• KAWANA Akihiko

  Disease Control and Prevention Center

• OKA Shinichi

  AIDS Clinical Center

• KIMURA Satoshi

  AIDS Clinical Center

• KUDO Koichiro

  Disease Control and Prevention Center

• KANO Shigeyuki

  Disease Control and Prevention Center Research Institute International Medical Center of Japan

Bibliographic Information

Other Title

• アーテスネート静注と血液透析による支持療法で救命しえた重症熱帯熱マラリアの1例
• 症例 アーテスネート静注と血液透析による支持療法で救命しえた重症熱帯熱マラリアの1例
• ショウレイ アーテスネート ジョウチュウ ト ケツエキ トウセキ ニ ヨル シジ リョウホウ デ キュウメイ シエタ ジュウショウ ネッタイ ネツ マラリア ノ 1レイ

Abstract

We report a 54-year-old Japanese man who contracted severe falciparum malaria after visiting West African countries. The patient presented with Plasmodium falciparum parasitemia of 10% on admission and was successfully treated with intravenous artesunate combined with continuous hemodiafiltration. We found that intravenous artesunate had excellent antimalarial activity with rapid parasite clearance and that few adverse effects were observed compared to those reported for intravenous quinine treatment. Supportive therapy was indispensable for saving the life of the patient. Few cases of intravenous artesunate treatment are reported in Japan because the drug has not been legally registered. We wish to emphasize the efficacy of intravenous artesunate with general supportive therapy in the treatment of possible imported severe malaria patients in Japanese medical settings.

Journal

• Kansenshogaku Zasshi

  Kansenshogaku Zasshi 80 (6), 706-710, 2006

  The Japanese Association for Infectious Diseases

Keywords

• falciparum malaria
• artesunate
• hemodiafiltration

Details

• CRID: 1390001205049726720
• NII Article ID: 10018393921
• NII Article ID: 130004331352
• NII Book ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.80.706
• ISSN: 1884569X
• ISSN: 03875911
• NDL BIB ID: 8596335
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8596335
• Web Site: https://search.jamas.or.jp/link/ui/2007107533
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed