Novel Deconjugative Esterification of 2-Cyclohexylideneacetic Acids through 4-(Pyrrolidin-1-yl)pyridine-catalyzed Carbodiimide Couplings
4-(Pyrrolidin-1-yl)pyridine-catalyzed deconjugative esterification of 2-cyclohexylideneacetic acids afforded isopropyl 2-(cyclohex-1-enyl)acetate by employing 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride as a coupling reagent. On the other hand, 4-(pyrrolidin-1-yl)pyridine-catalyzed esterification with 1,3-dicyclohexylcarbodiimide was not accompanied by deconjugation and gave isopropyl 2-cyclohexylideneacetate.
- Chemistry letters
Chemistry letters 35(11), 1286-1287, 2006-11-05
The Chemical Society of Japan