Highly Efficient Synthesis and Imaging Studies of an Arylpiperazine Derivative as a 5-HT_<1A> Receptor Imaging Agent

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著者

    • PARK Sang Hyun
    • Radiation Application Research Division, Korea Atomic Energy Research Institute
    • GWON Hui Jeong
    • Radiation Application Research Division, Korea Atomic Energy Research Institute
    • JANG Seung Ho
    • Radiation Application Research Division, Korea Atomic Energy Research Institute
    • LEE Hyosun
    • Department of Chemistry, Kyungpook National University

抄録

A novel and straightforward microwave synthesis of a new arylpiperazine derivative <B>3</B> which has an N<SUB>2</SUB>S<SUB>2</SUB> moiety has been developed and radiolabeled with an optimum radionuclide of technetium in the presence of a borohydride exchange resin (BER) as a reducing agent. According to the present study this new radiolabeled compound <B>4</B> could have the potential for a diagnostic application as an imaging agent of a serotonin neuroreceptor.

収録刊行物

  • Chemistry letters  

    Chemistry letters 35(11), 1304-1305, 2006-11-05 

    The Chemical Society of Japan

参考文献:  11件

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各種コード

  • NII論文ID(NAID)
    10018405352
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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