Highly Efficient Synthesis and Imaging Studies of an Arylpiperazine Derivative as a 5-HT_<1A> Receptor Imaging Agent
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A novel and straightforward microwave synthesis of a new arylpiperazine derivative <B>3</B> which has an N<SUB>2</SUB>S<SUB>2</SUB> moiety has been developed and radiolabeled with an optimum radionuclide of technetium in the presence of a borohydride exchange resin (BER) as a reducing agent. According to the present study this new radiolabeled compound <B>4</B> could have the potential for a diagnostic application as an imaging agent of a serotonin neuroreceptor.
- Chemistry Letters
Chemistry Letters 35(11), 1304-1305, 2006-11-05
The Chemical Society of Japan