3-ベンジリデンミオスミンおよび3-シンナミリデンミオスミン類縁体のワモンゴキブリニコチン性アセチルコリン受容体に対する親和性

• Ikeda Izumi

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University

• Utsunomiya Tsuyoshi

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University

• Sadamitsu Miki

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University

• Ozoe Yoshihisa

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University

• Mochida Kazuo

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University

書誌事項

タイトル別名

• Affinity of 3-benzylidene- and 3-cinnamylidenemyosmine analogues for Periplaneta americana nicotinic acetylcholine receptors

抄録

3-Benzylidenemyosmine analogues with substituents at the ortho-, meta-, and para-positions of the phenyl ring and 3-cinnamylidenemyosmine analogues with substituents at a para-position of the phenyl ring were synthesized. The affinity of the synthesized compounds for nicotinic acetylcholine receptors (nAChRs) in the nerve cord of the American cockroach (Periplaneta americana L.) was determined by radioligand binding assay using [³H]epibatidine. Of the compounds tested, 3-(2,4-dihydroxybenzylidene)myosmine 3 and 3-(4-hydroxybenzylidene)myosmine 4 displayed the highest potency, with IC₅₀ values of 0.120 and 0.310 μM, respectively. 3-(4-Dimethylaminobenzylidene)myosmine 15 with a para-dimethylamino group on the benzylidene moiety displayed moderate affinity (IC₅₀=5.49 μM). On the other hand, cinnamylidene analogues, 3-(4-dimethyl­amino­cinnamylidene)myosmine 16 and 3-cinnamylidenemyosmine 17, displayed moderate affinity, with IC₅₀ values of 2.07 and 3.52 μM, respectively.

収録刊行物

• 日本農薬学会誌（Ｊｏｕｒｎａｌ　ｏｆ　Ｐｅｓｔｉｃｉｄｅ　Ｓｃｉｅｎｃｅ）

  日本農薬学会誌（Ｊｏｕｒｎａｌ　ｏｆ　Ｐｅｓｔｉｃｉｄｅ　Ｓｃｉｅｎｃｅ） 31 (4), 417-419, 2006

  日本農薬学会

キーワード

• nicotinic acetylcholine receptor
• 3-benzylidenemyosmine
• American cockroach

詳細情報

• CRID: 1390001205210063232
• NII論文ID: 110004850997
• NII論文ID: 10018408801
• NII論文ID: 130004445066
• NII書誌ID: AA11818622
• DOI: 10.1584/jpestics.g06-11
• ISSN: 13490923
• ISSN: 03851559
• ISSN: 1348589X
• NDL書誌ID: 8582278
• Web Site: http://ir.lib.shimane-u.ac.jp/25428
• Web Site: https://agriknowledge.affrc.go.jp/RN/2010732766
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8582278
• Web Site: http://www.jstage.jst.go.jp/article/jpestics/31/4/31_4_417/_pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10877855
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • NDL-Digital
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可