Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells

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著者

    • OGUSHI Mariko
    • Department of Food Science and Technology, Faculty of Marine Science, Tokyo University of Marine Science and Technology
    • YOSHIE STARK Yumiko
    • Department of Food Science and Technology, Faculty of Marine Science, Tokyo University of Marine Science and Technology
    • SUZUKI Takeshi
    • Department of Food Science and Technology, Faculty of Marine Science, Tokyo University of Marine Science and Technology

抄録

To study the anti-tumor activity of sea cucumber extracts, human colon adenocarcinoma Caco-2 cells were exposed to hot water extract of sea cucumber. Morphological changes with apoptotic bodies were observed in the cells treated with the extract. We demonstrated the induction of apoptosis using phosphatidylserine translocation (APOPercentage Assay kit), terminal deoxynucleotide transferase-mediated dUTP-biotin nick-end labeling (TUNEL), and DNA fragmentation observed as DNA ladder. These results show that apoptosis was induced by a high molecular weight fraction in a dose dependent manner. These data suggest that water soluble and high molecular weight compounds from sea cucumber might exhibit anti-tumor activity by triggering apoptosis. The apoptosis-inducing activity may contribute to cancer chemopreventive effects of sea cucumber.

収録刊行物

  • Food science and technology research  

    Food science and technology research 12(4), 290-294, 2006-11-01 

    Japanese Society for Food Science and Technology

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各種コード

  • NII論文ID(NAID)
    10018441263
  • NII書誌ID(NCID)
    AA11320122
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    13446606
  • データ提供元
    CJP書誌  J-STAGE 
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