Slide-ring materials: new polymeric materials for DDS

DOI Web Site 24 References
  • Kidowaki Masatoshi
    Department of Advanced Materials Science, Graduate School of Frontier Sciences, The University of Tokyo CREST, Japan Science and Technology Agency (JST)
  • Kataoka Toshiyuki
    Department of Advanced Materials Science, Graduate School of Frontier Sciences, The University of Tokyo
  • Ito Kohzo
    Department of Advanced Materials Science, Graduate School of Frontier Sciences, The University of Tokyo CREST, Japan Science and Technology Agency (JST)

Bibliographic Information

Other Title
  • ナノバイオサイエンス　　環動高分子材料―ＤＤＳ用の新しい高分子材料―
  • 環動高分子材料--DDS用の新しい高分子材料
  • カンドウ コウブンシ ザイリョウ DDSヨウ ノ アタラシイ コウブンシ ザイリョウ
  • new polymeric materials for DDS
  • ―DDS用の新しい高分子材料―

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Abstract

We reviewed the fundamental aspects and applications of slide-ring materials as new polymeric materials for DDS. The slide-ring gel is one of the slide-ring materials using sliding features most effectively and has movable cross-linking junctions. As a result, it exhibited mechanical properties quite different from chemical gels, rather close to biomaterials. The small angle neutron scattering studies of the slide-ring gels revealed that the pulley effect relaxed the inhomogeneous structure in the slide-ring gels. In addition, we introduced the sol-gel transition of methylated polyrotaxane as a new thermoreversible DDS system. Finally, we discussed the application of the slide-ring materials to DDS with the future view.

Journal

  • Drug Delivery System

    Drug Delivery System 21 (6), 592-598, 2006

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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