慢性活動性Ｅｐｓｔｅｉｎ‐Ｂａｒｒ　Ｖｉｒｕｓ感染症

• 木村 宏

  名古屋大学大学院医学系研究科ウイルス学分野

書誌事項

タイトル別名

• Chronic Active Epstein-Barr Virus Infection

抄録

Epstein-Barr virus (EBV) is a ubiquitous virus and is related to various diseases. Primary EBV infection is usually asymptomatic, and it sometimes progresses to infectious mononucleosis, which resolves spontaneously after the emergence of EBV-specific immunity. But, in some apparently immunocompetent hosts, chronic infections can develop. Chronic active EBV infection (CAEBV) is characterized by chronic or recurrent infectious mononucleosis-like symptoms, such as fever, extensive lymphadenopathy, hepatosplenomegaly, and pancytopenia. Patients with CAEBV have high viral loads in their peripheral blood and/or an unusual pattern of EBV-related antibodies. This disease is rare but severe with high morbidity and mortality. Recent advances in technology have increased our understanding of CAEBV pathophysiology, indicating that the clonal expansion of EBV-infected T or natural killer (NK) cells plays a central role in the pathogenesis of CAEBV. However, it remains unclear whether CAEBV is truly a monoclonal lymphoproliferative disorder. In this review, I summarize the clinical feature of CAEBV and discuss our current understanding of the pathogenicity of the disease.

収録刊行物

• 日本小児血液学会雑誌

  日本小児血液学会雑誌 20 (6), 572-580, 2006

  特定非営利活動法人　日本小児血液・がん学会

キーワード

• Epstein-Barr virus
• CAEBV
• T cells
• natural killer cells

詳細情報

• CRID: 1390282679319997312
• NII論文ID: 130004117963
• NII論文ID: 10018449195
• NII書誌ID: AN10080852
• DOI: 10.11412/jjph1987.20.572
• ISSN: 18844723
• ISSN: 09138706
• Web Site: https://search.jamas.or.jp/link/ui/2007118423
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可