臍帯血移植後に血清Ｅｏｓｉｎｏｐｈｉｌ　Ｃａｔｉｏｎｉｃ　Ｐｒｏｔｅｉｎ値が高値を呈し気管支喘息様症状を呈したＢｒｏｎｃｈｉｏｌｉｔｉｓ　Ｏｂｌｉｔｅｒａｎｓ　Ｏｒｇａｎｉｚｉｎｇ　Ｐｎｅｕｍｏｎｉａ（ＢＯＯＰ）の１症例

DOI 参考文献18件
  • 荻野 芽子
    神戸大学大学院医学系研究科成育医学講座小児学科
  • 森 健
    神戸大学大学院医学系研究科成育医学講座小児学科
  • 矢内 友子
    神戸大学大学院医学系研究科成育医学講座小児学科
  • 早川 晶
    神戸大学大学院医学系研究科成育医学講座小児学科
  • 竹島 泰弘
    神戸大学大学院医学系研究科成育医学講座小児学科
  • 松尾 雅文
    神戸大学大学院医学系研究科成育医学講座小児学科

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  • Serum Eosinophil Cationic Protein Level Measurement under the Case of Infantile Acute Lymphoblastic Leukemia with Lung Complication after Cord Blood Transplantation

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It is difficult to distinguish bronchial asthma from bronchiolitis obliterans organizing pneumonia (BOOP), when dyspnea with wheeze is revealed after allogeneic stem cell transplantation. However, to clarify the cause of wheeze is important because treatment and prognosis are quite different between bronchial asthma and BOOP. We described here infantile acute lymphoblastic leukemia (ALL) for an 8-month-old female case that developed respiratory disorder with wheeze after unrelated cord blood transplantation (CBT). She got onset of infantile ALL, and underwent CBT from an HLA-one-locus-mismatched unrelated donor at the first complete remission. When dyspnea with wheeze appeared two months after CBT, she was treated with methylprednisolone pulse therapy as the possibility of lung graft-versus-host-disease (GVHD) could not be excluded. Blood examination revealed an increase of serum eosinophil cationic protein (ECP) levels (111 μg/l, compared to a normal range of less than 8.8 μg/l), which indicates that dyspnea with wheeze was a symptom of asthmatic BOOP. An effective treatment with steroid inhalation was applied. As a result, serum ECP level measurement was shown to be a useful diagnostic tool and indicator for clinical course in the case of lung complication with wheeze after CBT.

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