PROPHYLACTIC EFFECT OF FOSFOMYCIN ON POSTOPERATIVE INFECTION IN GASTROENTEROLOGICAL SURGERY
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- SHINAGAWA NAGAO
- Department of Surgery, Nagoya Midori Municipal Hospital
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- MIZUNO ISAMU
- Department of Surgery, Nagoya Midori Municipal Hospital
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- FUKUI TAKUJI
- Department of Surgery, Nagoya Midori Municipal Hospital
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- TAKEYAMA HIROMITSU
- Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences
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- YASUDA AKIRA
- Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences
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- MATSUMOTO KOUZOU
- Department of Cardiovascular Surgery, Nagoya City University Graduate School of Medical Sciences
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- UEDA NOBUHISA
- Department of Surgery, Matsunami General Hospital
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- MOURI NORIAKI
- Department of Surgery, Inabe General Hospital
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- NAGASAKI TAKAYA
- Department of Surgery, Bisai Hospital
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- YOKOYAMA TAKASHI
- Department of Surgery, Hiroshima City Aki Citizen Hospital
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- SHINBARA KANAE
- Department of Surgery, Hiroshima City Aki Citizen Hospital
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- ISAKA MITSUHIRO
- Department of Surgery, Hiroshima City Aki Citizen Hospital
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- KURISU YOSHIHIRO
- Department of Surgery, Mazda Hospital, Mazda Motor Corporation
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- AKAGI SHINJI
- Department of Surgery, Mazda Hospital, Mazda Motor Corporation
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- TAGAWA KOHEI
- Department of Surgery, Mazda Hospital, Mazda Motor Corporation
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- KANO MIKIHIRO
- Department of Surgery, Mazda Hospital, Mazda Motor Corporation
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- NIITANI NAOMI
- Department of Surgery, Mazda Hospital, Mazda Motor Corporation
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- WATATANI YUSUKE
- Department of Surgery, Mazda Hospital, Mazda Motor Corporation
Bibliographic Information
- Other Title
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- 消化器外科手術を対象としたホスホマイシンの術後感染予防効果
- ショウカキ ゲカ シュジュツ オ タイショウ ト シタ ホスホマイシン ノ ジュツゴ カンセン ヨボウ コウカ
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Abstract
Fosfomycin (FOM), a drug with unique mechanism of action against bacteria, was prospectively compared with cefmetazole (CMZ) and flomoxef (FMOX) to assess its effectiveness in preventing postoperative infections after upper gastroenterological and hepatobiliary surgery. FOM (2g/dose), CMZ (1g/dose), or FMOX (1g/dose) was infused intravenously 2-3 times daily for basically 4 days including the day of surgery in order to examine whether or not infections would develop after surgery. According to the analysis results of 162 cases, efficacy in preventing infection was 86.8% for FOM, 73.1% for CMZ and 83.3% for FMOX, showing no significant differences among the 3 groups. Thus FOM was considered as efficacious as CMZ or FMOX in prophylaxis against postoperative infections. There were no adverse reactions in the FOM or CMZ group, but 3 cases of adverse reactions occurred in the FMOX group.<BR>Based on the above results, the usefulness of FOM for prophylaxis against postoperative infections has been confirmed. At present, the first-and second-generation cephems are most frequently used for prophylaxis against postoperative infections. In order to prevent an increase of resistant strains due to inappropriate use of these drugs, FOM, having no cross resistance with currently used drugs, is a promising candidate for prophylaxis against postoperative infections.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 59 (6), 417-427, 2006
Japan Antibiotics Research Association
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Details 詳細情報について
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- CRID
- 1390282680471515136
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- NII Article ID
- 130004396048
- 10018449312
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- NII Book ID
- AN00002626
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- COI
- 1:STN:280:DC%2BD2s7jsFKksg%3D%3D
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- ISSN
- 21865477
- 03682781
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- NDL BIB ID
- 8633038
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed