Correlation between the analgesic and antipyretic effects of aspirin and salicylic acid concentration in rabbits
-
- YAMANE JUNICHI
- Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
-
- SATO NAOTO
- Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
-
- OKADA HIDEHIKO
- Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
-
- HORI MAMI
- Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
-
- GUNJI AKIHIKO
- Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
-
- HAKOZAKI KOSUKE
- Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
-
- FUJII AKIRA
- Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
Bibliographic Information
- Other Title
-
- 家兎におけるアスピリンの鎮痛作用および解熱作用とサリチル酸血漿中濃度の相関性
Search this article
Abstract
In order to clarify the correlation between the analgesic and antipyretic effects of aspirin and salicylic acid concentration, a jaw-opening reflex test and pyrogenic test were performed under the presence of aspirin, and the corresponding plasma concentration of salicylic acid was measured using rabbits. The analgesic effect of aspirin determined by jaw-opening reflex was significantly dependent on plasma level. The antipyretic effect of aspirin obtained by the pyrogenic test was also significantly dependent on plasma level. A closer correlation was demonstrated between the integral antipyretic effect and integral plasma level of salicylic acid.
Journal
-
- ORAL THERAPEUTICS AND PHARMACOLOGY
-
ORAL THERAPEUTICS AND PHARMACOLOGY 25 (3), 73-79, 2006
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679711816832
-
- NII Article ID
- 130003840842
- 10018449584
-
- NII Book ID
- AN0023517X
-
- ISSN
- 18844928
- 02881012
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- CiNii Articles
-
- Abstract License Flag
- Disallowed