脱神経により廃用性萎縮をきたしたラット骨格筋に対する培養筋芽細胞の移植 Myoblasts transplantation into denervated rat muscles
原著The purpose of this investigation is to observe whether cultured my oblasts take in denervated muscle and differentiate myofiber without reinnervation. Cultured myoblasts survived in not only intact muscle but also denervated muscle without reinnervation at 1 week after transplantation. The cells differentiated myofibers in both intact and denervated muscles at 2 weeks and 4 weeks after transplantation. The ratio of denervated muscle weight to intact muscle weight decreased from 1 week to 4 weeks after myoblasts transplantation, but the decrease is not significant for first 2 weeks. These data suggest that transplanted myoblasts could survive and differentiate myofibers in denervated muscle and myoblasts transplantation before reinnervation may prevent denervated muscle atrophy and improve muscle regeneration after nerve repair.
慶應醫學 83(4), 251-255, 2006-12-25