高齢者口腔癌に対する多剤併用動注化学療法 [in Japanese] INTRA-ARTERIAL CHEMOTHERAPY WITH SEVERAL ANTICANCER AGENTS FOR ORAL CANCER IN ELDERLY PATIENTS [in Japanese]
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In elderly patients with head and neck cancer, a safe and radical treatment with which the incidence of systemic side effects is low is required. We developed a new combination intra-arterial and intra-venous chemotherapy with docetaxel (TXT), cisplatin (CDDP), peplomycin (PEP), and 5-FU (TCPF intra-arterial chemotherapy), and evaluated its usefulness and safety in such patients.<BR>From March 2002 to May 2005, 10 patients aged over 75 years with oral squamous cell carcinoma were treated with TCPF intra-arterial chemotherapy. The patients consisted of 5 males and 5 females aged from 75 to 84 years (median age, 80 years). The tumors were located in the tongue or oral floor in 8 patients, the buccal mucosa in one, and the upper gingiva in one. A catheter for intra-arterial administration was inserted via the superficial temporal artery or occipital artery. Continuous intra-arterial administration of 15 mg/m<SUP>2</SUP> TXT (day 1-5) and 10 mg/body PEP (day 6-10), intra-arterial administration of 7-15 mg/m<SUP>2</SUP> TXT (day 3) and 7-15 mg/m<SUP>2</SUP> CDDP (day 4, 5), and continuous intravenous administration of 250 mg/body/day 5FU (day 1-10) were performed as 1 course. The second course was performed 4 weeks after the completion of the first course in patients for whom it was required. Radiotherapy was additionally performed in one patient. Excision biopsy in 7 patients, and radical excision in 2 were performed after the completion of this treatment.<BR>The effects of this method on the primary lesions were CR 8/10 (80%), PR 2/10 (20%), and pathological CR 6/9 (67%). As side effects, no cerebrovascular disorder was detected, but grades 2-3 mucositis and alopecia on the intra-arterial administration side were observed, without marked systemic disorders. These results indicated that this chemotherapy is useful and safe, and can be applied to as a radical treatment method elderly patients with high risks.
- Japanese jornal of Head and Neck Cancer
Japanese jornal of Head and Neck Cancer 32(4), 439-444, 2006-12-25
Japan Society for Head and Neck Cancer