Age-Dependent Changes in Iron Deposition in the Gerbil Hippocampus

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  • YOO Ki-Yeon
    Department of Anatomy, College of Medicine, Hallym University
  • HWANG In Koo
    Department of Anatomy, College of Medicine, Hallym University
  • KANG Il-Jun
    Department of Food Science and Nutrition, Hallym University
  • KANG Tae-Cheon
    Department of Anatomy, College of Medicine, Hallym University
  • LEE Hak-Ju
    Division of Wood Chemistry & Microbiology, Korea Forest Research Institute
  • KANG Ha-Young
    Division of Wood Chemistry & Microbiology, Korea Forest Research Institute
  • LEE Hyeon Yong
    School of Biotechnology and Bioengineering, Kangwon National University
  • OH Yang-Seok
    Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University
  • WON Moo Ho
    Department of Anatomy, College of Medicine, Hallym University

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抄録

In this study, we focused on age-dependent changes in intracellular iron deposition in the gerbil hippocampus. At 1 month of age (PM 1), iron reactivity was weak in the gerbil hippocampus. At this time, cells in the polymorphic layer of the dentate gyrus showed weak iron reactivity. At PM 3, iron reactivity in cells had not changed significantly. Thereafter, iron reactivity in the CA1-3 regions and in the dentate gyrus increased with time until PM 18. At PM 24, iron reactivity in all the subfields was similar to that at PM 18. In animals aged PM 18-24, iron positive cells had various shapes, and had processes which contained iron. These results suggest that the increase of iron deposition may be associated with normal aging and that the iron deposition in the aged hippocampus is different according to hippocampal subfields.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 56 (1), 21-28, 2007

    公益社団法人 日本実験動物学会

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