Effects of Xylene and Formaldehyde Inhalations on Oxidative Stress in Adult and Developing Rats Livers

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著者

    • Kum Cavit KUM Cavit
    • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Adnan Menderes University
    • SEYREK Kamil
    • Department of Biochemistry, Faculty of Veterinary Medicine, Adnan Menderes University
    • BOYACIOGLU Murat
    • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Adnan Menderes University

抄録

In this study, it was aimed to demonstrate the possible oxidative stress caused by exposure of xylene and formaldehyde (HCHO) on liver tissue, and on body and liver weights in adult as well as developing rats. The rats (96 female Sprague-Dawley) were randomly divided into four groups: embryonic day 1 (Group 1), 1-day-old infantile rats (Group 2), 4- week-old rats (Group 3) and adult rats (Group 4). The animals were exposed to gases of technical xylene (300 ppm), HCHO (6 ppm) or technical xylene + HCHO (150 ppm + 3 ppm), 8 hours per day for 6 weeks. Superoxide dismutase (SOD) and catalase (CAT) activities, and glutathione (GSH) and malondialdehyde (MDA) levels were evaluated. In addition, body and liver weights were determinated. Compared to the control animals, body and liver weights were decreased in the embryonic day 1 group (P<0.001, P<0.01, respectively) and the 1-day-old infantile group (P<0.001). Liver weight was increased in the 4-week-old group (P<0.01). SOD activities were decreased in the 4-week-old rats exposed to HCHO (P<0.01). CAT activities increased in the embryonic day 1 group (P<0.05). GSH levels were decreased in the 1-day-old infantile group (P<0.01), and MDA levels was increased in the embryonic day 1 group (P<0.05) as compared with the respective control groups. As to GSH and MDA levels in adult and 4-week-old animals, no statistically significant differences were observed (P>0.05). The present study indicates that exposures to xylene, HCHO and a mixture of them are toxic to liver tissue, and developing female rats are especially more adversely affected. Furthermore, the results of this study show that adult female rats could better tolerate the adverse effects of these toxic gases.<br>

収録刊行物

  • Experimental animals  

    Experimental animals 56(1), 35-42, 2007-01-01 

    Japanese Association for Laboratory Animal Science

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各種コード

  • NII論文ID(NAID)
    10018453442
  • NII書誌ID(NCID)
    AA11032321
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13411357
  • NDL 記事登録ID
    8597989
  • NDL 雑誌分類
    ZS7(科学技術--医学)
  • NDL 請求記号
    Z54-H752
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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