Template Based on Nano-Patterns of Polypeptide LB Film

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  • ポリペプチドＬＢ膜におけるナノパターン構造のテンプレートとしての応用
  • ポリペプチド LBマク ニ オケル ナノパターン コウゾウ ノ テンプレート ト シテ ノ オウヨウ

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Abstract

Self-assembling nanostructures of a molecular membrane at an air-water interface were studied using rod-like peptide building blocks. The polypeptides were a triblock-type amphiphile with a hydrophilic helix at the center and hydrophobic helices at the termini. CD spectra measurements showed that the polypeptides perform a helix-coil structural transition through ionization of the hydrophilic block owing to pH change in aqueous media, and are pH-responsive molecular components. AFM observation revealed that the polypeptides self-assemble into a phase-separated structure, with a two-dimensional ordered arrangement (stripe pattern morphology) in the monolayer. And the subphase pH affected the surface structure at the air-water interface, which suggested pH-controllable switching (disappear/recovery) of the nano-pattern in the molecular membrane system. The triblock copolypeptide LB film was applied as a nano-template, i.e., an iron nanoparticle with external coating of hydrophobic alkyl chains was specifically attached to the hydrophobic lanes in the nano-pattern, resulting in fabrication of their joined nano-wire reflecting the lane-like pattern in the monolayer.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 63 (12), 781-790, 2006

    The Society of Polymer Science, Japan

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