Recent Progress on Squaric Acid Research in Bioorganic Fields

• Shinada Tetsuro

  Graduate School of Science. Osaka City University

• Isida Toshikazu

  日東化成株式会社

• Ohfune Yasufumi

  Graduate School of Science. Osaka City University

Bibliographic Information

Other Title

• 生命科学研究におけるスクアリン酸の活用とその進歩

Abstract

Squaric acid belongs to a class of oxocarbons and exhibits unique physicochemical properties, e.g., strong acidity, aromaticity, strained ring, electron deficiency, and metal chelating ability. Squaric acid has received considerable attention as a carboxylic acid mimic in medicinal chemistry, a novel chromophore in material science, a new chelator in inorganic chemistry, and a building block of quinones, triquinanes, cyclopentenones, and furanones in organic synthesis. Recently, squaric acid diesters are employed for a variety of applications in scientific fields as a linker to construct novel bioconjugate molecules. This review will describes recent progress on the use of squaric acid focused on bioorganic research.

Journal

• Journal of Synthetic Organic Chemistry, Japan

  Journal of Synthetic Organic Chemistry, Japan 65 (1), 30-43, 2007

  The Society of Synthetic Organic Chemistry, Japan

Keywords

• squaric acid
• bioisostere
• pharmacophore
• linker
• bioconjugate molecule
• squarine

Details

• CRID: 1390282680315550464
• NII Article ID: 10018461767
• NII Book ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.65.30
• ISSN: 18836526
• ISSN: 00379980
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed