MPAI (Mass Probes Aided Ionization) Method for Total Analysis of Biomolecules by Mass Spectrometry

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  • HONDA Aki
    Department of Applied Chemistry, Keio University CREST of Japan Science and Technology Agency
  • HAYASHI Shinichiro
    Department of Applied Chemistry, Keio University
  • HIFUMI Hiroki
    Department of Applied Chemistry, Keio University
  • HONMA Yuya
    Department of Applied Chemistry, Keio University
  • TANJI Noriyuki
    Department of Applied Chemistry, Keio University
  • IWASAWA Naoko
    Department of Applied Chemistry, Keio University
  • SUZUKI Yoshio
    Department of Applied Chemistry, Keio University
  • SUZUKI Koji
    Department of Applied Chemistry, Keio University CREST of Japan Science and Technology Agency

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Abstract

We have designed and synthesized various mass probes, which enable us to effectively ionize various molecules to be detected with mass spectrometry. We call the ionization method using mass probes the “MPAI (mass probes aided ionization)” method. We aim at the sensitive detection of various biological molecules, and also the detection of bio-molecules by a single mass spectrometry serially without changing the mechanical settings. Here, we review mass probes for small molecules with various functional groups and mass probes for proteins. Further, we introduce newly developed mass probes for proteins for highly sensitive detection.

Journal

  • Analytical Sciences

    Analytical Sciences 23 (1), 11-15, 2007

    The Japan Society for Analytical Chemistry

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