サツマイモ茎葉の血圧降下作用 [in Japanese] Hypotensive Effect of Sweetpotato Tops [in Japanese]
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（1）サツマイモ茎葉の80％エタノール抽出液にACE阻害活性が認められた．活性の強さは茎葉中の部位で異なり，葉身部，茎部，葉柄部の順であった．<BR>（2） 80％エタノール抽出液に含まれるカフェ酸誘導体にACE阻害活性が認められた．活性の強さは，おおよそカフェオイル基の数に比例し，3,4,5-triCQA, 3,4-diCQA, 4,5-diCQA, ChA, 3,5-diCQA, CAの順であった．<BR>（3）サツマイモ茎葉を配合した飼料を摂取したSHRは茎葉の添加量依存的に血圧上昇が緩やかになる傾向を示した．<BR>以上のことより，サツマイモ茎葉によるSHRの血圧上昇抑制傾向は，カフェ酸誘導体類のACE阻害が一つの要因と推察された．
Sweetpotato tops exhibited angiotensin I-converting enzyme (ACE) inhibitory activity, with different levels of activity in the constituent parts of the tops. Leaves showed the highest activity, while that of stems and petioles was much reduced. Since there appeared to be a relationship between ACE inhibitory activity and the total content of the caffeoylquinic acids in the constituent parts, the ACE inhibitory activity of each caffeoylquinic acid was analyzed. 3,4,5-tri-<I>O</I>-caffeoylquinic acid (3,4,5-triCQA) showed the strongest activity, followed by 3,4-di-<I>O</I>-caffeoylquinic acid (3,4-diCQA), and 4,5-di-<I>O</I>-caffeoylquinic acid (4,5-diCQA). Spontaneously hypertensive rats (SHR) which were orally administered sweetpotato tops exhibited dose-dependent suppression in blood pressure increases in comparison with the control group. These results suggest that sweetpotato tops have a hypotensive effect in SHR, which is at least in part due to the ACE inhibitory activity of caffeoylquinic acids.
- NIPPON SHOKUHIN KOGYO GAKKAISHI
NIPPON SHOKUHIN KOGYO GAKKAISHI 54(1), 45-49, 2007-01-15
Japanese Society for Food Science and Technology