骨髄生検にて診断し得たＡｓｉａｎ　ｖａｒｉａｎｔの血管内大細胞型Ｂ細胞リンパ腫

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タイトル別名
  • Asian variant of intravascular large B-cell lymphoma diagnosed by bone marrow biopsy
  • 骨髄生険にて診断し得たAsian variantの血管内大細胞型B細胞リンパ腫
  • コツズイセイケン ニテ シンダン シエタ Asian variant ノ ケッカン ナイ ダイ サイボウガタ B サイボウ リンパ シュ

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抄録

A 63-year-old male presented with fever and general malaise in June 2004. On admission hepatosplenomegaly was apparent, but without lymphadenopathy. The laboratory examination revealed pancytopenia and increased levels of lactate dehydrogenase, direct bilirubin and soluble interleukin-2 receptor. Histological analysis of the bone marrow biopsy specimen demonstrated proliferation of atypical lymphoid cells positive for CD20 in the small capillaries, leading to the diagnosis of the Asian variant of intravascular large B-cell lymphoma (AIVL). The presence of rearrangement of the immunoglobulin gene confirmed the diagnosis. The patient responded well to CHOP therapy followed by seven courses of rituximab-combined CHOP therapy and has remained in complete remission up to the present. This case implies that bone marrow biopsy could be a useful examination for diagnosing AIVL and that rituximab-combined chemotherapy could improve survival in patients with the disease.

収録刊行物

  • 臨床血液

    臨床血液 48 (1), 61-63, 2007

    一般社団法人 日本血液学会

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