骨髄生検にて診断し得た Asian variant の血管内大細胞型B細胞リンパ腫 Asian variant of intravascular large B-cell lymphoma diagnosed by bone marrow biopsy

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抄録

A 63-year-old male presented with fever and general malaise in June 2004. On admission hepatosplenomegaly was apparent, but without lymphadenopathy. The laboratory examination revealed pancytopenia and increased levels of lactate dehydrogenase, direct bilirubin and soluble interleukin-2 receptor. Histological analysis of the bone marrow biopsy specimen demonstrated proliferation of atypical lymphoid cells positive for CD20 in the small capillaries, leading to the diagnosis of the Asian variant of intravascular large B-cell lymphoma (AIVL). The presence of rearrangement of the immunoglobulin gene confirmed the diagnosis. The patient responded well to CHOP therapy followed by seven courses of rituximab-combined CHOP therapy and has remained in complete remission up to the present. This case implies that bone marrow biopsy could be a useful examination for diagnosing AIVL and that rituximab-combined chemotherapy could improve survival in patients with the disease.

収録刊行物

  • 臨床血液 = The Japanese Journal of Clinical Hematology  

    臨床血液 = The Japanese Journal of Clinical Hematology 48(1), 61-63, 2007-01-30 

    The Japanese Society of Hematology

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各種コード

  • NII論文ID(NAID)
    10018493117
  • NII書誌ID(NCID)
    AN00252940
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    04851439
  • NDL 記事登録ID
    8616738
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z19-295
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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