切れ込み核や単球様の形態を呈した形質細胞性白血病

• 平瀬 伸尚

  国立病院機構　小倉病院　内科

• 牟田 正一

  国立病院機構　小倉病院　研究検査科

• 安部 康信

  九州大学大学院医学系研究科病態制御内科学

• 牟田 耕一郎

  九州大学大学院医学系研究科病態制御内科学

書誌事項

タイトル別名

• Plasma cell leukemia presenting with cleaved nuclei and a monocytoid appearance
• キレコミ カク ヤ タンキュウ サマ ノ ケイタイ オ テイシタ ケイシツ サイボウセイ ハッケツビョウ

抄録

A 74-year-old man presented with anemia, thrombocytopenia and leukocytosis with 41% abnormal cells having cleaved and monocytoid nuclei. The bone marrow was infiltrated with 43.6% abnormal cells that were negative for peroxidase staining and positive for PAS staining. Surface antigen analysis revealed no expression of CDs 2, 3, 4, 8, 10, 19, 20, 13 or 33. Serum immunoelectrophoresis detected a monoclonal band, which was identifiable as κ-type IgA protein. Immunostaining also revealed expression of IgA and κ-type in the abnormal cells. The patient was diagnosed as having plasma cell leukemia but the morphological findings were unusual. Surface antigen analysis revealed expression of CD38 later. This case suggests that immunostaining of abnormal cells is required for the differential diagnosis of plasma cell leukemia in leukocytosis.

収録刊行物

• 臨床血液

  臨床血液 48 (1), 64-66, 2007

  一般社団法人 日本血液学会

キーワード

• Plasma cell leukemia
• Immunostaining

詳細情報

• CRID: 1390001205032390400
• NII論文ID: 10018493122
• NII書誌ID: AN00252940
• DOI: 10.11406/rinketsu.48.64
• COI: 1:STN:280:DC%2BD2s7hsl2ltw%3D%3D
• ISSN: 18820824
• ISSN: 04851439
• NDL書誌ID: 8616773
• PubMed: 17313079
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8616773
• Web Site: https://search.jamas.or.jp/link/ui/2007162210
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可