Pure red cell aplasia successfully treated with rituximab in a patient with relapsed diffuse large B-cell lymphoma

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  • SUZUKI Takayuki
    Department of Hematology, Ohme Municipal General Hospital
  • KUMAGAI Takashi
    Department of Hematology, Ohme Municipal General Hospital
  • KITANO Asako
    Department of Hematology, Ohme Municipal General Hospital
  • KUBO Humito
    Department of Hematology, Ohme Municipal General Hospital
  • TABATA Mikio
    Department of Laboratory Medicine, Ohme Municipal General Hospital
  • KIMURA Yuji
    Department of Pathology, Ohme Municipal General Hospital
  • MIURA Osamu
    Department of Hematology, Tokyo Medical and Dental University
  • IMAI Yasufumi
    Department of Hematology, Ohme Municipal General Hospital

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Other Title
  • Diffuse large B-cell lymphomaの再発時に合併し，rituximab治療が奏効した赤芽球癆
  • Diffuse large B cell lymphoma ノ サイハツジ ニ ガッペイ シ rituximab チリョウ ガ ソウコウ シタ セキガキュウロウ

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Abstract

Malignant lymphoma is often accompanied by an autoimmune disorder. Here, we describe a 82-year-old woman with pure red cell aplasia (PRCA) complicated with relapsed diffuse large B-cell lymphoma. Primary treatment involving chemotherapy, continuous oral administration of prednisolone and a single infusion of rituximab was unsuccessful for both diseases, but the following treatments with 3 courses of rituximab alone for once a week dramatically improved the PRCA as well as the lymphoma. As PRCA complicated with lymphoma is rare, the ideal therapeutic strategy has not yet been established for it. Rituximab may be a good alternative for treating such cases.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 48 (1), 67-70, 2007

    The Japanese Society of Hematology

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