PRTR化学物質の各種核内受容体に対する結合性 Binding Affinity of PRTR Chemicals to Various Human Nuclear Receptors

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著者

    • 井上 大介 INOUE Daisuke
    • 大阪大学大学院工学研究科環境・エネルギー工学専攻 Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University
    • 松井 久恵 MATSUI Hisae
    • 大阪大学大学院工学研究科環境・エネルギー工学専攻 Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University
    • 清 和成 [他] SEI Kazunari
    • 大阪大学大学院工学研究科環境・エネルギー工学専攻 Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University
    • 楊 敏 YANG Min
    • 中国科学院生態環境研究中心 State Key Lab of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
    • 荒金 淳 ARAGANE Jun
    • 三菱電機(株)先端技術総合研究所 Advanced Technology R&D Center, Mitsubishi Electric Co.
    • 西川 淳一 NISHIKAWA Jun-ichi
    • 大阪大学大学院薬学研究科 Department of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University
    • 池 道彦 IKE Michihiko
    • 大阪大学大学院工学研究科環境・エネルギー工学専攻 Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University

抄録

Since the 1990s, population decreases, reproductive anomalies and malformations of highly aquatic animals have been increasingly reported. One possible cause is considered to be endocrine disruptive effects induced by environmental contaminants through a direct interaction with nuclear receptors, not only with steroid hormone receptors but also with other ones. In this study, we examined the binding affinities of 20 chemicals, which are registered in the Japanese Pollutant Release and Transfer Register (PRTR) and have been abundantly discharged into aquatic environments to eight human nuclear receptors and assessed their potential endocrine disruptive effects. Of the 20 PRTR chemicals tested, nonylphenol diethoxylate, telephthalic acid (TPA), and linear dodecyl-benzensulfonate (DBS) bound to at least two receptors at high concentrations. TPA and DBS enhanced the activities of both retinoic acid receptor (RAR) γ and vitamin D receptor (VDR) in a dose-dependent manner. This suggests that TPA and DBS may disturb the vitamin D endocrine functions mediated by a VDR-VDR homodimer or a VDR-RAR heterodimer. Also, our results indicate that endocrine disruptors unsuspected under the current assessment criteria could potentially bind to various nuclear receptors and disrupt endocrine systems mediated by such receptors.

収録刊行物

  • 水環境学会誌 = Journal of Japan Society on Water Environment  

    水環境学会誌 = Journal of Japan Society on Water Environment 30(2), 89-94, 2007-02-10 

    Japan Society on Water Environment

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各種コード

  • NII論文ID(NAID)
    10018496834
  • NII書誌ID(NCID)
    AN10372439
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    09168958
  • NDL 記事登録ID
    8683460
  • NDL 雑誌分類
    ZN5(科学技術--建設工学・建設業--都市工学・衛生工学)
  • NDL 請求記号
    Z16-1045
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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