リン酸オセルタミビルの改良合成に向けた研究 Studies into Improved Synthesis of Oseltamivir Phosphate

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Oseltamivir phosphate (Tamiflu®) 1 is the only orally active anti-influenza drug. Although constant supply of 1 has been required to avert a possible lethal influenza outbreak, the current commercial synthetic route depends on (-) -shikimic acid 2 of limited availability. New and advantageous synthetic routes to 1 via the catalytic asymmetric reaction have been developed recently, revealing the evolution of synthetic methodology.

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  • 有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN

    有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 65(2), 151-152, 2007-02-01

    The Society of Synthetic Organic Chemistry, Japan

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