Determination of Atenolol and Metoprolol by Capillary Electrophoresis with Tris(2,2′-bipyridyl)ruthenium(II) Electrochemiluminescence Detection

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  • HUANG Jianshe
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
  • SUN Jinying
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
  • ZHOU Xiaoguang
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
  • YOU Tianyan
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

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タイトル別名
  • Determination of Atenolol and Metoprolol by Capillary Electrophoresis with Tris(2,2'-bipyridyl)ruthenium(II) Electrochemiluminescence Detection
  • Determination of Atenolol and Metoprolol by Capillary Electrophoresis with Tris 2 2 bipyridyl ruthenium 2 Electrochemiluminescence Detection

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Capillary electrophoresis (CE) coupling with a tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy)32+) electrochemiluminescence (ECL) detection technique was developed for the analysis of two β-blockers, atenolol (AT) and metoprolol (ME). The parameters that influence the separation and detection, including the buffer pH and concentration, the separation voltage, the detection potential and Ru(bpy)32+ concentration, were optimized in detail. The calibration curve was linear over a concentration range of two or three orders of magnitude for the two β-blockers. The detection limits for AT and ME were 0.075 and 0.005 µM (S/N = 3). The relative standard deviations (n = 8) of the ECL intensity and the migration time were 2.65 and 0.22% for AT, 2.82 and 0.34% for ME, respectively. The proposed method was applied to determine AT and ME in spiked urine samples; satisfactory results were obtained.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 23 (2), 183-188, 2007

    社団法人 日本分析化学会

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