Quantitative Analysis of Methacycline Hydrochloride by Direct Potentiometry Using the Internal Solid Contact Sensor
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- SUN Xian Xiang
- Department of Chemical Engineering, Jiangsu Polytechnic University
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- ABOUL-ENEIN Hassan Y.
- Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Center (NCR)
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Abstract
An internal solid contact sensor (ISCS) for the determination of methacycline hydrochloride (MC·Cl), Pt/PPy/PVC(MC-PT), is described, based on the use of conducting poly(pyrrole) (PPy) as solid contact material and MC-phosphotungstate (PT) as the ion exchanger and dibutyl phthalate (DBP) as the plasticizer. A direct potentiometric method for the quantitative analysis of MC·Cl is also described. Under the condition of pH 2.7, the linear concentration range, slope (25°C) and detection limit of the sensor are 6.4 × 1.0-6 - 3.0 × 1.0-3 M, 52.4 ± 0.2 mV/decade and 4.4 × 1.0-6 M, respectively. The response time is <5 s. The determinations of MC·Cl in tablets were carried out by direct potentiometry. The average recovery and relative standard deviation are 100.1 and 0.7% (n = 4), respectively.
Journal
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- Analytical Sciences
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Analytical Sciences 23 (2), 231-233, 2007
The Japan Society for Analytical Chemistry
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Details 詳細情報について
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- CRID
- 1390001204258480896
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- NII Article ID
- 10018497812
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- NII Book ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL BIB ID
- 8628920
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed