Effect on Pulmonary Function of Inhaled Isotonic Disodium Cromoglycate in Case of Childhood Asthma

  • KANNO Noriko
    Department of Pediatrics, Dokkyo University School of Medicine
  • YOSHIHARA Shigemi
    Department of Pediatrics, Dokkyo University School of Medicine
  • HUKUDA Norimasa
    Department of Pediatrics, Dokkyo University School of Medicine
  • YAMADA Yumi
    Department of Pediatrics, Dokkyo University School of Medicine
  • ABE Toshio
    Department of Pediatrics, Dokkyo University School of Medicine
  • ARISAKA Osamu
    Department of Pediatrics, Dokkyo University School of Medicine

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Other Title
  • クロモグリク酸ナトリウム吸入液等張製剤切り替えによる小児喘息児の肺機能への影響

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Abstract

This article describes the results of a clinical study conducted to assess the effects of inhalation of an isotonic, in place of hypotonic, solution of disodium cromoglycate (DSCG) on the pulmonary function parameters and severity of cough in asthmatic children.The retrospective study included 68 asthmatic children who developed asthma before the age of six years, and who were receiving treatment with inhaled disodium cromoglycate (hypotonic solution).The DSCG solution was changed to an isotonic from hypotonic solution in January 2004.Significantly greater improvement of the pulmonary function parameters was observed following inhalation of isotonic DSCG solution than that following inhalation of the hypotonic solution.For the same age, the% V50, % V25 were significantly higher in the group inhaling isotonic DSCG solution than in that inhaling the hypotonic DSCG solution.The number of cough was significantly lesser in the children inhaling the isotonic DSCG solution than in those inhaling the hypotonic DSCG solution.

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