q-Space Imaging Using Small Magnetic Field Gradient

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<i>q</i>-space diffusion analysis is a method to obtain the probability density function of the translational displacement of diffusing water molecules. Several quantities can be extracted from the function that indicate a characteristic of the water diffusion in tissue, e.g., the mean displacement of the diffusion, probability for zero displacement, and kurtosis of the function. These quantities are expected to give information about the microstructure of tissues in addition to that obtained from the apparent diffusion coefficient (ADC); however, this method requires high <i>q</i> (i.e., high <i>b</i>) values, which are undesirable in practical applications of the method using clinical magnetic resonance (MR) imaging equipment. We propose a method to obtain certain quantities that indicate a characteristic of the diffusion and that uses low <i>q</i>-value measurements. The quantities we can obtain are the moments of translational displacement, <i>R</i>; the <i>n</i>-th order moment is defined as the average of <i>R</i><sup><i>n</i></sup> (<i>n</i>: integer). Kurtosis can also be calculated from the second and fourth moments. We tried to map the moments and kurtosis using clinical MR imaging equipment. We also estimated the inherent errors of the moments obtained. Our method requires precision in measuring spin echo signals and setting <i>q</i> values rather than using high <i>q</i>-value measurements. Although our results show that further error reductions are desired, our method is workable using ordinary clinical MR imaging equipment.<br>

収録刊行物

  • Magnetic resonance in medical sciences : MRMS  

    Magnetic resonance in medical sciences : MRMS 5(4), 179-189, 2006-12-31 

    Japanese Society for Magnetic Resonance in Medicine

参考文献:  28件

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被引用文献:  3件

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各種コード

  • NII論文ID(NAID)
    10018514713
  • NII書誌ID(NCID)
    AA11648770
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13473182
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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