Transient Splenial Lesion of the Corpus Callosum after Acute Withdrawal of Antiepileptic Drug : A Case Report

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著者

    • HONDA Kazuhiro
    • Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
    • NISHIMIYA Jin
    • Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
    • SATO Hideki
    • Department of Psychiatry, Kohnodai Hospital, National Center of Neurology and Psychiatry
    • MUNAKATA Maki
    • Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
    • KAMADA Masaki
    • Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
    • IWAMURA Akihide
    • Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
    • NEMOTO Hideaki
    • Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
    • SAKAMOTO Takashi
    • Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
    • YUASA Tatsuhiko
    • Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry

抄録

Transient lesions at the splenium of the corpus callosum (SCC) have been reported after withdrawal of specific antiepileptic drugs (AED), though the pathophysiology of the lesions remains unclear. We examined and treated a schizophrenic patient who developed a transient SCC lesion after withdrawal of the AED, carbamazepine. Interestingly, the SCC lesion was accompanied by the onset of diabetes insipidus, a state of arginine-vasopressin (AVP) insufficiency. Because carbamazepine is shown to potentiate the effect of AVP, our case suggests that an insufficiency of AVP followed by withdrawal of AED could contribute to the pathogenesis of a transient SCC lesion.<br>

収録刊行物

  • Magnetic resonance in medical sciences : MRMS  

    Magnetic resonance in medical sciences : MRMS 5(4), 211-215, 2006-12-31 

    Japanese Society for Magnetic Resonance in Medicine

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各種コード

  • NII論文ID(NAID)
    10018514806
  • NII書誌ID(NCID)
    AA11648770
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    13473182
  • データ提供元
    CJP書誌  J-STAGE 
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