Electrochemical A-Ring Bromination of Estrogens
A-ring bromination of estrogens has been achieved by constant current electrolysis of the solutions of these substrates and Et<SUB>4</SUB>NBr in appropriate solvents. Thus, electrolysis consuming 2 F mol<SUP>−1</SUP> charge gave mixtures of 2- and 4-estrogens (1:1.1–2.5; up to 97%), whereas 4 F mol<SUP>−1</SUP> charge experiments yielded 2,4-dibromoestrogens as the sole products.
- Bulletin of the Chemical Society of Japan
Bulletin of the Chemical Society of Japan 80(2), 407-409, 2007-02-15