Electrochemical A-Ring Bromination of Estrogens

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  • Electrochemical A Ring Bromination of Estrogens

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<jats:title>Abstract</jats:title> <jats:p>A-ring bromination of estrogens has been achieved by constant current electrolysis of the solutions of these substrates and Et4NBr in appropriate solvents. Thus, electrolysis consuming 2 F mol−1 charge gave mixtures of 2- and 4-estrogens (1:1.1–2.5; up to 97%), whereas 4 F mol−1 charge experiments yielded 2,4-dibromoestrogens as the sole products.</jats:p>

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