Effect of Benzylic Oxygen on the Cytotoxic Activity for Colon 26 Cell Line of Phenolic Lignans

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The cytotoxic activity for colon 26 cell line of matairesinol, oxidized matairesinol, 9,9′-epoxylignan and oxidized 9,9′-epoxylignan were examined. (−)-Matairesinol (Mat 1) showed greatest cytotoxic activity (LC<SUB>50</SUB>=9 μg/ml) of the lactone-type lignans. 7,7′-Oxomatairesinol having same steric configuration as that of (−)-matairesinol showed greater activity (LC<SUB>50</SUB>=25 μg/ml) than hydroxy or mono-oxomatairesinol. The activities of 9,9′-epoxylignan and 7,7′-oxo-9,9′-epoxylignan having same steric configurations as (−)-matairesinol were weaker than that of corresponding matairesinols. Different activity levels were observed between enantiomers.

収録刊行物

  • Bioscience, biotechnology, and biochemistry

    Bioscience, biotechnology, and biochemistry 70(12), 2942-2947, 2006-12-23

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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各種コード

  • NII論文ID(NAID)
    10018523805
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    8596492
  • NDL 雑誌分類
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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