Inhibitory Effect of Lactobacillus gasseri TMC0356 and Lactobacillus GG on Enhanced Vascular Permeability of Nasal Mucosa in Experimental Allergic Rhinitis of Rats
The nasal vascular permeability of ovablumin (OVA)-sensitized Brown Norway rats was evaluated by analyzing a brilliant blue concentration in perfusate from the nose after exposure of the nasal mucus to OVA. Oral administration of <I>Lactobacillus</I> GG and <I>L. gasseri</I> TMC0356 significantly inhibited the increase in nasal vascular permeability (<I>P</I><0.01). The serum IgE of the tested rats also decreased, although the change was not statistically significant. These results indicate that <I>Lactobacillus</I> GG and <I>L. gasseri</I> TMC0356 might alleviate nasal allergic symptoms by suppressing the increase in nasal vascular permeability caused by local inflammation associated with allergic rhnititis.
- Bioscience, biotechnology, and biochemistry
Bioscience, biotechnology, and biochemistry 70(12), 3025-3030, 2006-12-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry