Biosynthetic Origin of [<i>R</i>-(<i>Z</i>)]-4-Amino-3-chloro-2-pentenedioic Acid in<i>Streptomyces viridogenes</i>

  • HUTCHINSON Robin I.
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin
  • GRANT Russell J.
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin
  • MURPHY Cormac D.
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin

書誌事項

タイトル別名
  • Biosynthetic Origin of [R-(Z)]-4-Amino-3-chloro-2-pentenedioic Acid in Streptomyces viridogenes

この論文をさがす

抄録

The biosynthesis of the chlorinated amino acid [R-(Z)]-4-amino-3-chloro-2-pentenedioic acid (ACPA) was investigated. Feeding studies with Streptomyces viridogenes were conducted in resting cells. Substantial incorporation from [15N]- and [13C]-enriched glutamate and proline indicated that the biosynthetic origin of ACPA is one of these amino acids. Experiments with deuterated glutamate and proline imply that chlorination does not occur via a radical mechanism, but rather suggest that a FADH2-dependent halogenase is involved.

収録刊行物

参考文献 (17)*注記

もっと見る

詳細情報

問題の指摘

ページトップへ