Effects of xapA and guaA Disruption on Inosine Accumulation in Escherichia coli
A <I>xapA</I>-disrupted mutant was studied to minimize hypoxanthine production and to improve inosine productivity in mutants of <I>Escherichia coli</I>. The <I>xapA</I>-disrupted mutant accumulated 5.6 g/l of inosine from 40 g/l of glucose, while the parent strain accumulated 4.6 g/l. This result indicates that <I>xapA</I> is activated in <I>xapA</I>-positive inosine-producers and that <I>xapA</I> disruption might be useful for improving inosine productivity.
- Bioscience, biotechnology, and biochemistry
Bioscience, biotechnology, and biochemistry 70(12), 3069-3072, 2006-12-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry