Lactic Acid Bacteria (LAB) Bind to Human B- or H-Antigens Expressed on Intestinal Mucosa

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  • UCHIDA Hideaki
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University
  • KAWAI Yasushi
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University
  • KINOSHITA Hideki
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University
  • KITAZAWA Haruki
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University
  • MIURA Koh
    Department of Gastrointestinal and Colorectal Surgery, Tohoku University School of Medicine
  • SHIIBA Kenichi
    Department of Gastrointestinal and Colorectal Surgery, Tohoku University School of Medicine
  • HORII Akira
    Department of Molecular Pathology, Tohoku University School of Medicine
  • KIMURA Katsunori
    Division of Research and Development, Meiji Dairies Corporation
  • TAKETOMO Naoki
    Division of Research and Development, Meiji Dairies Corporation
  • ODA Munehiro
    Division of Research and Development, Meiji Dairies Corporation
  • YAJIMA Takaji
    Division of Research and Development, Meiji Dairies Corporation
  • SAITO Tadao
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University

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Twenty lactobacilli isolated from human feces were studied for binding to the human blood type B-antigen [Galα1-3 (Fucα1-2) Gal-] and H-antigen (Fucα1-2Gal-] expressed sugar chains in human intestinal mucosa. We found two strains, L. gasseri OLL2755 and L. gasseri OLL2877 that firmly adhere to human B-antigen, and we found L. gasseri OLL2827 bound to the H-antigen.

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