Disruption of ins-11, a Caenorhabditis elegans Insulin-Like Gene, and Phenotypic Analyses of the Gene-Disrupted Animal
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The insulin/insulin-like growth factor-I signaling (IIS) pathway regulates larval diapause, adult lifespan, fat metabolism, and stress-resistance in the nematode <I>Caenorhabditis elegans</I>. One of 38 <I>C. elegans</I> insulin-like genes, <I>ins-11</I>, was disrupted and phenotypic analyses of the gene-disrupted animal were performed. The gene-disruption exhibited a significant influence on the adult lifespan. It antagonized the lifespan extension induced by RNAi knockdown of another insulin-like gene, <I>ins-7</I>. Hence <I>ins-11</I> appears to be necessary for lifespan extension caused by a decrease in the IIS pathway. This is the first description of gene-disruption of the <I>C. elegans</I> insulin-like gene that suppresses the lifespan extension.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(12), 3084-3087, 2006-12-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry