Disruption of ins-11, a Caenorhabditis elegans Insulin-Like Gene, and Phenotypic Analyses of the Gene-Disrupted Animal

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  • KAWANO Tsuyoshi
    Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
  • NAGATOMO Ryosuke
    Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
  • KIMURA Yasuo
    Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
  • GENGYO-ANDO Keiko
    Department of Physiology, Tokyo Women’s Medical University School of Medicine CREST, JST
  • MITANI Shohei
    Department of Physiology, Tokyo Women’s Medical University School of Medicine CREST, JST

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  • Disruption of<i>ins-11</i>, a<i>Caenorhabditis elegans</i>Insulin-Like Gene, and Phenotypic Analyses of the Gene-Disrupted Animal

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Abstract

The insulin/insulin-like growth factor-I signaling (IIS) pathway regulates larval diapause, adult lifespan, fat metabolism, and stress-resistance in the nematode Caenorhabditis elegans. One of 38 C. elegans insulin-like genes, ins-11, was disrupted and phenotypic analyses of the gene-disrupted animal were performed. The gene-disruption exhibited a significant influence on the adult lifespan. It antagonized the lifespan extension induced by RNAi knockdown of another insulin-like gene, ins-7. Hence ins-11 appears to be necessary for lifespan extension caused by a decrease in the IIS pathway. This is the first description of gene-disruption of the C. elegans insulin-like gene that suppresses the lifespan extension.

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