An Anti-Estrogenic Lignan Glycoside, Tracheloside, from Seeds of Carthamus tinctorius
Access this Article
Search this Article
The lignan glycoside, tracheloside, was isolated from seeds of <I>Carthamus tinctorius</I> (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC<SUB>50</SUB> value of 0.31 μg/ml, a level of inhibition comparable to that of tamoxifen (IC<SUB>50</SUB> = 0.43 μg/ml).
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(11), 2783-2785, 2006-11-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry