Antioxidative and Anti-Inflammatory Activities of Polyhydroxyflavonoids of Scutellaria baicalensis GEORGI

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Abstract

The active ingredients of 'golden root' of <I>Scutellaria baicalensis</I> GEORGI (Huang-Qin), a valuable traditional Chinese medicine, are polyhydroxyflavonoids, namely baicalein, oroxylin A and wogonin. With the objective of overcoming their poor solubility and to investigate their structure and activity relationships, baicaleinyl 7-<I>O</I>-sulfate was prepared, and extensive comparative antioxidative and anti-inflammatory tests were conducted. All the polyhydroxyflavonoids exhibited significant antioxidative and free-radical scavenging activities. In respect of their nitric oxide (NO) inhibition, wogonin was superior to all the other flavonoids, while oroxylin A was most potent in the inhibition of lipid peroxidation. Wogonin proved to be the most potent (82.9% inhibition, <I>p</I><0.05) in its anti-inflammatory activity against carrageenan-induced rat hind paw edema. There was a correlation between the <I>in-vivo</I> anti-inflammatory activity and the <I>in-vitro</I> antioxidative activities.

Journal

Bioscience, Biotechnology, and Biochemistry  

Bioscience, Biotechnology, and Biochemistry 70(10), 2371-2380, 2006-10-23 

Japan Society for Bioscience, Biotechnology, and Agrochemistry

References:  43

Cited by:  2

Codes

  • NII Article ID (NAID) :
    10018525499
  • NII NACSIS-CAT ID (NCID) :
    AA10824164
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    09168451
  • NDL Article ID :
    8523699
  • NDL Source Classification :
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-G223
  • Databases :
    CJP  CJPref  NDL  J-STAGE