Effect of Dietary Cyclic Nigerosylnigerose on Intestinal Immune Functions in Mice

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著者

    • INOUE Shin-ichiro
    • Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
    • OKU Kazuyuki
    • Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
    • CHAEN Hiroto
    • Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
    • KOHNO Keizo
    • Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
    • FUKUDA Shigeharu
    • Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.

抄録

We examined the dietary effects of cyclic nigerosylnigerose (CNN), a dietary indigestible oligosaccharide with four <small>D</small>-glucopyranosyl residues linked by alternating α-(1→3)- and α-(1→6) glucosidic linkages, on the intestinal immune function of mice, and the effects were compared with those of α-(1→3)-linked oligosaccharide (nigerooligosaccharides, NOS) or α-(1→6)-linked oligosaccharide (isomaltooligosaccharides, IMO). BALB/c mice were fed with 1–5% CNN, 5% IMO, or 12.5% NOS for 4 weeks, and the intestinal mucosal immune responses were determined. In the 1–5% CNN fed groups, the amounts of IgA in feces increased significantly. In addition, IgA, transforming growth factor-β1 (TGF-β1), and interleukin-6 (IL-6) secretion by Peyer's patch (PP) cells were enhanced in CNN fed mice. In the 5% CNN group, pH in the cecum decreased, and the amounts of lactic acid and butyric acid increased. These findings were not observed in the NOS- or IMO-fed group of mice. They suggest that CNN supplementation changes the intestinal environment of microflora and indirectly enhances the immune function in the gut.

収録刊行物

  • Bioscience, biotechnology, and biochemistry  

    Bioscience, biotechnology, and biochemistry 70(10), 2481-2487, 2006-10-23 

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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各種コード

  • NII論文ID(NAID)
    10018525921
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    8523996
  • NDL 雑誌分類
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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