Effect of Dietary Cyclic Nigerosylnigerose on Intestinal Immune Functions in Mice

• HINO Keiko

  Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.

• KUROSE Mayumi

  Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.

• SAKURAI Takeo

  Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.

• INOUE Shin-ichiro

  Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.

• OKU Kazuyuki

  Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.

• CHAEN Hiroto

  Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.

• KOHNO Keizo

  Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.

• FUKUDA Shigeharu

  Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.

Abstract

We examined the dietary effects of cyclic nigerosylnigerose (CNN), a dietary indigestible oligosaccharide with four D-glucopyranosyl residues linked by alternating α-(1→3)- and α-(1→6) glucosidic linkages, on the intestinal immune function of mice, and the effects were compared with those of α-(1→3)-linked oligosaccharide (nigerooligosaccharides, NOS) or α-(1→6)-linked oligosaccharide (isomaltooligosaccharides, IMO). BALB/c mice were fed with 1–5% CNN, 5% IMO, or 12.5% NOS for 4 weeks, and the intestinal mucosal immune responses were determined. In the 1–5% CNN fed groups, the amounts of IgA in feces increased significantly. In addition, IgA, transforming growth factor-β1 (TGF-β1), and interleukin-6 (IL-6) secretion by Peyer’s patch (PP) cells were enhanced in CNN fed mice. In the 5% CNN group, pH in the cecum decreased, and the amounts of lactic acid and butyric acid increased. These findings were not observed in the NOS- or IMO-fed group of mice. They suggest that CNN supplementation changes the intestinal environment of microflora and indirectly enhances the immune function in the gut.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (10), 2481-2487, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• cyclic nigerosylnigerose
• immunoglobulin A (IgA)
• Peyer’s patch (PP)
• transforming growth factor-β1 (TGF-β1)
• interleukin-6 (IL-6)

Details

• CRID: 1390001206477384576
• NII Article ID: 10018525921
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.60215
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 8523996
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8523996
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60215
• Web Site: https://search.jamas.or.jp/link/ui/2007090812
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed