Royal Jelly Stimulates Bone Formation: Physiologic and Nutrigenomic Studies with Mice and Cell Lines
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- NARITA Yukio
- Nagaragawa Research Center, API Co., Ltd.
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- NOMURA Johji
- Faculty of Pharmaceutical Science, Kumamoto University
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- OHTA Shozo
- Nagaragawa Research Center, API Co., Ltd.
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- INOH Yoshikazu
- Nagaragawa Research Center, API Co., Ltd.
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- SUZUKI Kazu-Michi
- Nagaragawa Research Center, API Co., Ltd.
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- ARAKI Yoko
- Nagaragawa Research Center, API Co., Ltd.
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- OKADA Shinji
- Graduate School of Agricultural and Life Sciences, Department of Applied Biological Chemistry, The University of Tokyo
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- MATSUMOTO Ichiro
- Graduate School of Agricultural and Life Sciences, Department of Applied Biological Chemistry, The University of Tokyo
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- ISOHAMA Yoichiro
- Faculty of Pharmaceutical Science, Kumamoto University
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- ABE Keiko
- Graduate School of Agricultural and Life Sciences, Department of Applied Biological Chemistry, The University of Tokyo
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- MIYATA Takeshi
- Faculty of Pharmaceutical Science, Kumamoto University
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- MISHIMA Satoshi
- Nagaragawa Research Center, API Co., Ltd.
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Abstract
Royal jelly (RJ) has diverse physiological and pharmacological functions. We observed its weak estrogenic activity in the previous study. RJ stimulated the proliferation of mouse osteoblast-like MC3T3-E1 cells at 0.1 mg/ml, and the effect was blocked by the specific estrogen receptor antagonist ICI 182,780. The addition of 0.1–1.0 mg/ml RJ enhanced collagen production in culture medium. Oral administration of RJ to normal female mice for 9 weeks increased the ash content of their tibiae. DNA microarray analysis revealed significant changes in gene expression related to extracellular matrix formation when the femurs of mice fed RJ were analyzed. Quantitative reverse transcriptase-PCR (RT-PCR) confirmed up-regulation of procollagen I α1 gene expression. These data suggest that RJ as a whole or some of its individual components stimulates production of type I collagen and other activities for bone formation through action on osteoblasts.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (10), 2508-2514, 2006
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390282681454072192
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- NII Article ID
- 10018526055
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 8524140
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed