Antihyperglycemic Activity of Herb Extracts on Streptozotocin-Induced Diabetic Rats
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We investigated the effects of herb extracts, <I>Rhus verniciflua</I>, <I>Agrimonia pilosa</I>, <I>Sophora japonica</I>, and <I>Paeonia suffruticosa</I>, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of <I>Rhus verniciflua</I> extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (<I>P</I><0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by <I>Rhus verniciflua</I> extract supplementation. In addition, <I>Sophora japonica</I> and <I>Paeonia suffruticosa</I> extracts significantly reduced TBARS levels <I>versus</I> diabetic controls. Serum concentrations of liver-function marker enzymes, GOT and GPT, were also restored by <I>Rhus verniciflua</I> (50 mg/kg) supplementation in diabetic rats.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(10), 2556-2559, 2006-10-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry