Antihyperglycemic Activity of Herb Extracts on Streptozotocin-Induced Diabetic Rats

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著者

    • Zhou Song ZHOU Song
    • Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
    • KIM Ji Hye
    • Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
    • HONG Myung Hee
    • Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
    • SHIN Yong-Cheol
    • Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
    • KIM Gyung Jun
    • Department of Ophthalmology and Otorhinolaryngology, College of Oriental Medicine, Kyungwon University
    • KO Seong-Gyu
    • Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University

抄録

We investigated the effects of herb extracts, <I>Rhus verniciflua</I>, <I>Agrimonia pilosa</I>, <I>Sophora japonica</I>, and <I>Paeonia suffruticosa</I>, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of <I>Rhus verniciflua</I> extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (<I>P</I><0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by <I>Rhus verniciflua</I> extract supplementation. In addition, <I>Sophora japonica</I> and <I>Paeonia suffruticosa</I> extracts significantly reduced TBARS levels <I>versus</I> diabetic controls. Serum concentrations of liver-function marker enzymes, GOT and GPT, were also restored by <I>Rhus verniciflua</I> (50 mg/kg) supplementation in diabetic rats.

収録刊行物

  • Bioscience, biotechnology, and biochemistry  

    Bioscience, biotechnology, and biochemistry 70(10), 2556-2559, 2006-10-23 

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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各種コード

  • NII論文ID(NAID)
    10018526213
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    09168451
  • NDL 記事登録ID
    8524546
  • NDL 雑誌分類
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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