Antihyperglycemic Activity of Herb Extracts on Streptozotocin-Induced Diabetic Rats

• JUNG Chang Hwa

  Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University

• ZHOU Song

  Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University

• DING Guo Xun

  Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University

• KIM Ji Hye

  Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University

• HONG Myung Hee

  Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University

• SHIN Yong-Cheol

  Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University

• KIM Gyung Jun

  Department of Ophthalmology and Otorhinolaryngology, College of Oriental Medicine, Kyungwon University

• KO Seong-Gyu

  Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University

Abstract

We investigated the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (P<0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by Rhus verniciflua extract supplementation. In addition, Sophora japonica and Paeonia suffruticosa extracts significantly reduced TBARS levels versus diabetic controls. Serum concentrations of liver-function marker enzymes, GOT and GPT, were also restored by Rhus verniciflua (50 mg/kg) supplementation in diabetic rats.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (10), 2556-2559, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• herb extracts
• <I>Rhus verniciflua</I>
• blood glucose
• thiobarbituric acid reactive substances
• diabetic rats

Details

• CRID: 1390282681453748736
• NII Article ID: 10018526213
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.60238
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 8524546
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8524546
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60238
• Web Site: https://search.jamas.or.jp/link/ui/2007090819
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed