Tumor Antigen Occurs in N-Glycan of Royal Jelly Glycoproteins: Honeybee Cells Synthesize T-Antigen Unit in N-Glycan Moiety

• KIMURA Yoshinobu

  Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• USHIJIMA Takayuki

  Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• MAEDA Megumi

  Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• HAMA Yoichiro

  Department of Applied Biological Sciences, Faculty of Agriculture, Saga University

• KIMURA Mariko

  Department of Food System, Faculty of Food Culture, Kurashiki Sakuyo University

• OKIHARA Kiyoshi

  Yamada Apiculture Center Inc.

• SUGIMOTO Hiroyuki

  Yamada Apiculture Center Inc.

• YAMADA Hideo

  Yamada Apiculture Center Inc.

Bibliographic Information

Other Title

• Tumor Antigen Occurs in<i>N</i>-Glycan of Royal Jelly Glycoproteins: Honeybee Cells Synthesize T-Antigen Unit in<i>N</i>-Glycan Moiety

Abstract

In our previous paper (Kimura, Y., et al., Biosci. Biotechnol. Biochem., 67, 1852–1856, 2003), we found that a complex type N-glycans containing β1-3 galactose residue occurs on royal jelly glycoproteins. During structural analysis of minor components of royal jelly N-glycans, we found complex type N-glycans bearing both galactose and N-acetylgalactosamine residues. Detailed structural analysis of pyridylaminated oligosaccharide revealed that the newly found N-glycan had a complex type structure harboring a tumor marker (T-antigen) unit: Galβ1-3GalNAcβ1-4GlcNAcβ1-2Manα1-6 (Galβ1-3GalNAcβ1-4GlcNAcβ1-2Manα1-3) Manβ1-4GlcNAcβ1-4GlcNAc. To our knowledge, this may be the first report of the presence of the T-antigen unit in the N-glycan moiety of eucaryotic glycoproteins.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (10), 2583-2587, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• royal jelly
• T-antigen
• tumor marker
• insect <I>N</I>-glycan
• <I>Apis mellifera</I>

Details

• CRID: 1390001206477022976
• NII Article ID: 10018526317
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.60331
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 8524750
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8524750
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60331
• Web Site: https://search.jamas.or.jp/link/ui/2007090821
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed