Salicylic Acid and a Chitin Elicitor Both Control Expression of the CAD1 Gene Involved in the Plant Immunity of Arabidopsis

• GOTO Masao

  National Agriculture and Food Research Organization National Food Research Institute

• TAKANO-ISHIKAWA Yuko

  National Agriculture and Food Research Organization National Food Research Institute

• ONO Hiroshi

  National Agriculture and Food Research Organization National Food Research Institute

• YOSHIDA Mitsuru

  National Agriculture and Food Research Organization National Food Research Institute

• YAMAKI Kohji

  Japan International Research Center for Agricultural Sciences

• SHINMOTO Hiroshi

  National Agriculture and Food Research Organization National Food Research Institute Tamagawa University

書誌事項

タイトル別名

• Orally Administered Bisphenol A Disturbed Antigen Specific Immunoresponses in the Naieve Condition
• Orally Administered Bisphenol A Disturbed Antigen Specific Immunoresponses in the Naïve Condition
• Salicylic Acid and a Chitin Elicitor Both Control Expression of the<i>CAD1</i>Gene Involved in the Plant Immunity of<i>Arabidopsis</i>

抄録

Bisphenol A [2,2-bis(4-hydoxyphenyl)propane; BPA] is an endocrine disrupter widely used in polycarbonate plastics and epoxy resins. We investigated the effects of orally administered BPA on antigen-specific responses of the naïve immune system.<BR>BPA was orally administered to T cell receptor transgenic mice, and the antigen-specific responses of immune cells were investigated. Administered BPA moderately reduced interleukin (IL)-2, 4, and interferon (IFN)-γ secretion and increases in IgA and IgG2a production.<BR>Additionally, it was found that orally administered BPA increased antigen-specific IFN-γ production of T cells and modified whole antigen presenting cells (APCs) to suppress antigen-specific cytokine production from T cells.<BR>These findings suggest that BPA can augment the Th1-type responses of naïve immune systems, though the bioavailability of orally administered BPA was low in our experiments.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 71 (9), 2136-2143, 2007

  公益社団法人 日本農芸化学会

キーワード

• bisphenol A
• naïve immune responses
• Th1/2-balance
• oral administration

詳細情報

• CRID: 1390001206478668160
• NII論文ID: 10018526455
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.70004
• DOI: 10.1271/bbb.50700
• ISSN: 13476947
• ISSN: 09168451
• HANDLE: 2115/14840
• NDL書誌ID: 8073282
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8073282
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70004
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.50700
• Web Site: https://search.jamas.or.jp/link/ui/2008081577
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
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