Memory-Enhancing Effect of a Supercritical Carbon Dioxide Fluid Extract of the Needles of Abies koreana on Scopolamine-Induced Amnesia in Mice
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<I>Abies koreana</I> Wilson (<I>A. koreana</I>) is a shrub or broadly pyramidal evergreen tree endemic in the mountainous regions of South Korea. We obtained the essential oil (EO) from alpine needle leaves of <I>A. koreana</I> by the supercritical fluid extraction (SFE) method. EO was analyzed by gas chromatography–mass spectrometry (GC–MS), and 68 compounds were identified constituting 95.66% of the oil. The major components were elemol (11.17%), terpinen-4-ol (9.77%), sabinene (8.86%), 10(15)-cadien-4-ol (7.16%), α-terpineol (6.13%), α-pinene (6.07%) and γ-terpinene (4.71%). To investigate the memory-enhancing effects, we conducted a passive avoidance test using a scopolamine (1 mg/kg, ip)-induced amnesia mouse model. A peritoneal injection of EO from <I>A. koreana</I> (100 mg/kg) showed a memory enhancing effect of 72.7% compared with the control. These results suggest that EO of <I>A. koreana</I> may be a useful therapeutic agent against such amnesia-inducing diseases as Alzheimer and vascular dementia.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 70(8), 1821-1826, 2006-08-23
Japan Society for Bioscience, Biotechnology, and Agrochemistry