Memory-Enhancing Effect of a Supercritical Carbon Dioxide Fluid Extract of the Needles of Abies koreana on Scopolamine-Induced Amnesia in Mice

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著者

    • LIM Jongpil
    • Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
    • CHA Dong Seok
    • Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
    • KIM Jinmo
    • Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
    • JEON Sora
    • Department of Oriental Pharmacy, College of Pharmacy, Woosuk University
    • EUN Jaesoon
    • Department of Pharmacy, College of Pharmacy, Woosuk University
    • JEON Hoon
    • Department of Oriental Pharmacy, College of Pharmacy, Woosuk University

抄録

<I>Abies koreana</I> Wilson (<I>A. koreana</I>) is a shrub or broadly pyramidal evergreen tree endemic in the mountainous regions of South Korea. We obtained the essential oil (EO) from alpine needle leaves of <I>A. koreana</I> by the supercritical fluid extraction (SFE) method. EO was analyzed by gas chromatography–mass spectrometry (GC–MS), and 68 compounds were identified constituting 95.66% of the oil. The major components were elemol (11.17%), terpinen-4-ol (9.77%), sabinene (8.86%), 10(15)-cadien-4-ol (7.16%), α-terpineol (6.13%), α-pinene (6.07%) and γ-terpinene (4.71%). To investigate the memory-enhancing effects, we conducted a passive avoidance test using a scopolamine (1 mg/kg, ip)-induced amnesia mouse model. A peritoneal injection of EO from <I>A. koreana</I> (100 mg/kg) showed a memory enhancing effect of 72.7% compared with the control. These results suggest that EO of <I>A. koreana</I> may be a useful therapeutic agent against such amnesia-inducing diseases as Alzheimer and vascular dementia.

収録刊行物

  • Bioscience, biotechnology, and biochemistry  

    Bioscience, biotechnology, and biochemistry 70(8), 1821-1826, 2006-08-23 

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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各種コード

  • NII論文ID(NAID)
    10018527825
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    8040091
  • NDL 雑誌分類
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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